Abordagem baseada em plantas para o combate à Dengue: compostos ativos, alvos imunológicos e mecanismos de ação

Autores

DOI:

https://doi.org/10.48075/aes.v9i2.34118

Palavras-chave:

Vírus da Dengue, Fitoterápicos, Modulação imunológica, Alvos imunológicos

Resumo

A dengue continua sendo uma ameaça à saúde global, particularmente em regiões tropicais que não tenham vacinas eficazes ou tratamentos antivirais disponíveis. Esta revisão explora a abordagem baseada em plantas como abordagem promissora para o tratamento da dengue, concentrando-se em compostos bioativos, alvos imunológicos e mecanismos de ação. Objetivo: Explorar o potencial terapêutico dos fitoterápicos no manejo da dengue, destacando seus efeitos antivirais e imunomoduladores. Métodos: Nesta revisão, foi realizada uma pesquisa bibliográfica abrangente, com artigos revisados por pares sobre plantas medicinais e seus compostos bioativos em relação à dengue. Resultados: Plantas como Andrographis paniculata, Azadirachta indica, Carica papaya, Curcuma longa, Tinospora cordifolia e Euphorbia hirta contêm compostos bioativos como flavonóides, alcalóides, terpenóides e saponinas. Esses compostos inibem a replicação viral, modulam respostas imunes e têm alvo alvos imunológicos críticos, incluindo proteínas virais e produção de citocinas. Por exemplo, a quercetina suprime a replicação viral, enquanto a berberina reduz as citocinas pró-inflamatórias, potencialmente reduzindo as complicações da dengue. Os terpenóides, com suas propriedades anti-inflamatórias, podem mitigar a ativação imunológica excessiva. As saponinas podem aumentar as defesas antivirais, diminuindo a carga viral e a gravidade da doença. Conclusão: Os fitoterápicos oferecem potencial significativo como terapias adjuvantes para a dengue, com propriedades antivirais e imunomoduladoras. No entanto, desafios relacionados à padronização, controle de qualidade e variabilidade nas concentrações de compostos ativos devem ser abordados para garantir aplicações clínicas. A integração de fitoterápicos com terapias convencionais pode fornecer estratégias eficazes e sustentáveis para o manejo da dengue globalmente.

Biografia do Autor

Seyi Enitan, Department of Medical Laboratory Science, Babcock University, Ilishan-Remo, Ogun State.

Department of Medical Laboratory Science, School of Public and Allied Health, Babcock University, Ilishan-Remo, 121109, Ogun State, Nigeria.

Richard Akele, University of Brighton

Department of Biomedical Science, School of Applied Science, University of Brighton, Brighton ES BN2 4AT, United Kingdom

Khairah Adedotun, Federal Teaching Hospital Lokoja

Department of Microbiology, Federal Teaching Hospital Lokoja, 260006, Kogi State, Nigeria.

Michael Iduh, Usmanu Danfodiyo University Sokoto

Department of Medical Microbiology, School of Medical Laboratory Science, Usmanu Danfodiyo University Sokoto, 840104, Sokoto State, Nigeria

Ernest Ohanu, Pamo University of Medical Science

Department of Medical laboratory Science, Pamo University of Medical Science, Elelenwo, 500102, Port Harcourt, Rivers State, Nigeria.

Aolat Adetosoye, Aberdeen University

Department of Microbiology, Aberdeen University, Aberdeen, AB24 3FX, GB, United Kingdom

Abiodun Adetola, Olabisi Onabanjo University Teaching Hospital, Sagamu

Department of Medical Laboratory Science, Olabisi Onabanjo University Teaching Hospital, Sagamu, 121102, Ogun State, Nigeria

Michael Dickson, Nottingham Trent University

Department of Biotechnology, School of Science and Technology, Nottingham Trent University, Mansfield, NG18 5BH, United Kingdom

Aimanose Ediale, Naval Medical Center, Victoria Island

Department of Medical Laboratory Science, Naval Medical Center, Victoria Island, Lagos 106104, Lagos State, Nigeria. 

Chinwendu Ikonne, Ikate Primary Healthcare Centre

Department of Medical Laboratory Science, Ikate Primary Healthcare Centre, Ikate, 106104, Lagos State, Nigeria.

Mercy Ade-Ige, Nigerian Institute of Medical Research, Yaba

Department of Population Genomics and Cancer Research, Nigerian Institute of Medical Research,

Yaba, Lagos 101245, Lagos State, Nigeria

Oluwanifemi Ajayi , Babcock University, Ilishan-Remo

Department of Medical Laboratory Science, School of Public and Allied Health, Babcock University, Ilishan-Remo 121109, Ogun State, Nigeria.

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Publicado

24-10-2024

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ENITAN, S.; AKELE, R.; ADEDOTUN, K.; IDUH, M.; OHANU, E.; ADETOSOYE, A.; ADETOLA, A.; DICKSON, M.; EDIALE, A.; IKONNE, C.; ADE-IGE, M.; AJAYI , O. Abordagem baseada em plantas para o combate à Dengue: compostos ativos, alvos imunológicos e mecanismos de ação. Acta Elit Salutis, [S. l.], v. 9, n. 2, 2024. DOI: 10.48075/aes.v9i2.34118. Disponível em: https://saber.unioeste.br/index.php/salutis/article/view/34118. Acesso em: 14 mar. 2025.

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v. 9 n. 2 (2024): Acta Elit Salutis

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