Morphological and quantitative evaluation of mucous acini of the sublingual gland of chronic diabetes and quercetine supplemented rats
DOI:
https://doi.org/10.48075/aes.v1i1.23679Keywords:
diabetes mellitus, quercetin, sublingual glandAbstract
Chronic diabetes causes several morphofunctional changes in the parenchyma of the salivary glands due to increased oxidative stress and also due to metabolic, vascular and neuropathic complications. Whereas salivary glands are crucial for maintaining the functional and structural integrity of the oral cavity; we aimed to evaluate the morphological and quantitative parameters of mucous acini of the sublingual gland of rats with chronic diabetes and supplemented with quercetin. Twenty rats were randomly assigned to four groups (n = 5): Normoglycemic (C); Quercetin supplemented normoglycemic (CQ); Diabetics (D) and Quercetin supplemented diabetics (DQ). CQ and DQ rats received quercetin (200 mg.Kg-1 body mass) in water for 120 days. The data obtained from the quantitative analysis showed no significant difference in acinar density between all groups analyzed (p> 0.05). Morphometric analysis revealed a higher mean acinar area in group QC compared to the other groups (p <0.001). In the condition of diabetes, quercetin supplementation did not alter the morphochemical parameters of the mucous acini of these glands. The largest average acinar area observed in rats from the quercetin-supplemented normoglycemic group (QC) could be related to the ability of this antioxidant to regulate cellular, metabolic and gene expression processes.
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