Search of variant hemoglobins in the population of Francisco Beltrão - Paraná

Abstract

Hemoglobinopathies are a group of autosomal changes, most often recessive, characterized by the production of structurally abnormal hemoglobins (Hb) or by the imbalance in the synthesis rate of globin chains. Considering that all these hemoglobinopathies determine important clinical manifestations, it is important to emphasize the importance of early laboratory diagnosis of these pathologies, avoiding the deleterious consequences of the disease. Given the above, the present work aimed to research variant hemoglobins in the population of Francisco Beltrão, Paraná. Patients with a medical blood count who were treated at the services of a Francisco Beltrão Clinical Analysis Laboratory (LAC) were approached after blood collection. The objectives of the work were exposed, as well as the methodology. Blood was collected according to laboratory protocol by venous puncture with EDTA as anticoagulant. After the samples were used by the laboratory, they were sent to the support laboratory for hemoglobin electrophoresis and the blood count results were passed through the LAC. Fifty-two patients were part of the research, however, none showed alteration in hemoglobin composition. We emphasize the importance of continuing the research in the region in a larger group of people focusing on those with anemia or hematimetric changes since the miscegenatory characteristics corroborate the existence of variant hemoglobins in the site.