Analysis of the prevalence of venous thrombosis, Khorana score and survival in patients with pancreatic cancer at the Cascavel’s Cancer Hospital

Abstract

Episodes of venous thromboembolism (VTE) are a frequent complication in cancer patients, being even more frequent in cases of pancreatic neoplasia, having a great impact on the morbidity of these patients. Within this context, the Khorana score is a tool that stratifies the risk of cancer patients to have VTE. In this study, we aimed to assess the prevalence of VTE in patients followed up with pancreatic cancer at the Hospital of cancer from Cascavel-PR, in addition to correlating the Khorana score and overall survival, as well to identifying whether the score was able to predict patients with episodes of thromboembolism. As a result, within a cohort of 111 patients, 16 (14.41%) had episodes of VTE. In addition, the median survival of the population studied was 4 months, and the main variables related to survival were: sex, presence of metastases, QT intention and KPS. Regarding the Khorana score, it was unable to predict patients who would have episodes of VTE, in addition to its variables not being related to survival and mortality. Therefore, the importance of new studies that seek to validate the Khorana score or the search for other tools capable of predicting VTE episodes is highlighted.