Ação da curcumina na atenuação da atrofia muscular e sarcopenia: uma revisão narrativa

Caio Ortiz Regula; Guilherme Vannucchi Portari

doi:10.36453/cefe.2025.34232

Autores/as

Caio Ortiz Regula Universidade Federal do Triângulo Mineiro (UFTM), Uberaba, Brasil https://orcid.org/0009-0000-5130-1362
Guilherme Vannucchi Portari Universidade Federal do Triângulo Mineiro (UFTM), Uberaba, Brasil https://orcid.org/0000-0002-0299-9001

DOI:

https://doi.org/10.36453/cefe.2025.34232

Palabras clave:

curcumina, sistema músculo esquelético, atrofia

Resumen

INTRODUÇÃO: O músculo esquelético é fundamental para o corpo humano, mas pode sofrer degradação por fatores fisiológicos ou patológicos. Pesquisas com fitoquímicos, especialmente a curcumina da cúrcuma, indicam efeitos positivos na recuperação e prevenção da atrofia muscular, como diminuição de proteínas envolvidas no catabolismo, redução de inflamação e radicais livres, além de melhorias na função muscular e mitocondrial.
OBJETIVO: Realizar uma revisão de estudos que demonstrem a ação da curcumina na musculatura esquelética de modo a verificar seus benefícios, caso haja, na condição de atrofia muscular.
MÉTODOS: O trabalho consiste em uma revisão narrativa de estudos experimentais in vivo selecionados previamente utilizando como pesquisa as bases de dados PubMed, Scielo, Web of Science, Scopus e Wiley Online Library e as palavras-chave: muscular atrophy e curcumin.
RESULTADOS: A pesquisa obteve dezoito (n=18) estudos, sendo quinze (n=15) estudos experimentais com animais e três (n=3) estudos experimentais com humanos. Foram observados de forma geral diminuição da sinalização atrófica muscular por meio da inibição de enzimas participantes da via ubiquitina-proteassoma e da ubiquitinação de proteínas, além da redução de mediadores inflamatórios, atividade do fator nuclear kappa beta e contenção de radicais livres.
CONCLUSÃO: Os resultados tendem a apontar que a curcumina pode inibir ou atenuar a atrofia muscular ocasionada por diferentes cenários, porém são necessários ainda mais estudos, principalmente clínicos, para comprovação de sua ação e eficácia.

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